Phase I study to assess the effect on healthy male volunteers of ketoconazole on the Pharmacokinetics of a single dose of AZD5069 administered orally.

Inclusion Criteria

• - Healthy male volunteers aged 18 to 50 years (inclusive).
• - Veins suitable for cannulation or repeated venipuncture.
• - Healthy volunteers with neutrophil counts within the laboratory normal reference range at Screening
• - Body mass index (BMI) ≥18.0 and ≤30.0 kg/m2 calculated from height and weight at screening; minimum weight 50 kg and maximum weight 100 kg.
• - Non-smokers or ex-smokers with no smoking history for the last 3 months prior to screening and a smoking history of less than 10 pack years (1 pack year = tobacco consumption corresponding to 20 cigarettes smoked per day for 1 year) at screening.