%22%2F%3E%0A%3Cdefs%3E%0A%3Cpattern%20id%3D%22pattern0%22%20patternContentUnits%3D%22objectBoundingBox%22%20width%3D%221%22%20height%3D%221%22%3E%0A%3Cuse%20xlink%3Ahref%3D%22%23image0_10319_58637%22%20transform%3D%22scale(0.00350877%200.0142857)%22%2F%3E%0A%3C%2Fpattern%3E%0A%3Cimage%20id%3D%22image0_10319_58637%22%20width%3D%22285%22%20height%3D%2270%22%20xlink%3Ahref%3D%22data%3Aimage%2Fpng%3Bbase64%2CiVBORw0KGgoAAAANSUhEUgAAAR0AAABGCAYAAADxVED7AAAAAXNSR0IArs4c6QAAE2xJREFUeF7tXY3xJUUR38nAIwHFBBQTQEhAMAE5E1BMQDABIAG9iwCMgCMCIQGBCCCDsX7r9FZvb%2Fd0z%2B68938cvVVXd3Vvdz56en7T31OWfJICSYGfNQVqrb8FAUopX9%2BDEOUenWQfSYGkwGNRoNb6i2VZ%2FrIsy1%2BXZcG%2F8fy4LMunpZSPbznaBJ1bUjfbTgo8IAVqrQCbjxjYyFG%2BKKU8v9XQE3RuRdlsNynwYBRo0s0ny7J8EBjaB6WUl4H3hl9J0BkmWX6QFPjpUaDW%2BqtlWb5clgV%2FR56vSylvRV4cfSdBZ5Ri%2BX5S4CdGgROAQzN8p5TyavZ0E3RmUzTbSwo8EAUuAA5m8VkpBYbmqU%2BCzlRyZmNJgcehwEXAwURelVLemT2jBJ3ZFM32kgIPQIEJgINZ%2FFhKeTZ7Ogk6syma7SUFnpgCkwCHZvFmKeW7mVNK0JlJzWwrKfDEFJgMOJjN81LKi5nTStCZSc1sKynwhBRocTj%2FGXCLR0b7YSnl08iL0XcSdKKUyveSAg9OgVorAGfNowo8ny3LAgnmcwekpkcnJ%2BgEVidfSQo8OgVqrYg0jrq3N%2Bml1opv8K31%2FLuU8t7M%2BSfozKRmtpUUeAIK1Fr%2F3nKpvN6R0AnA2Ww0tVYACqQd65kemZyg4y1T%2Fp4UeGAKtOTNqM3lLVm%2Bohmev%2B1M8btSypszSZCgM5Oa2VZS4I4UqLX%2BvuVTRXo1vVC11tppYHqsToJOZLnynaTAg1Fg0DXedXvXWiHpmImgpZSpODG1sQdblxxOUuC1pMBMwAGBaq3IPofUpD4JOq8lG%2BWkkgJxCgy4xkOBfbVWGJb%2F1BnB1KjklHTia51vJgWenAIDnqoQ4DRJB1UE4QGzngSdJ1%2F5HEBS4Ako4HiqIK1slf5G6uAEYnUSdJ5gvbPLpMCTUqDd2ICIY%2B1BIfUflLrHuN0BsTnfLMuCb7%2FXwKjWivKl%2F%2BpM8OBqv0KMVK%2BuUC%2B%2FTQrcgQIBwzHKilqApI0QYPQV6uUsy0LABBXrN4ZBeWoFwQSdOzBNdpEUuEIBz7u0LAuC93oBfl73KF0BAMIfSEVwnyNS%2Be327wQdj4L5e1LgdaFA0HCMQlsAHbq%2FCvlU%2BBMtwi7JRZLQF%2B0HRCVPq6mTks7rwp05j9eOAoEUBcx59VLVWpEKgfus8Kw2mBaxDHtNzx3u0Y2kICR%2BEgh533R%2FT9C5RL78OClwGwoEa%2BNsbnGREvFxKQU2mvVp4IXgP7jFz0o%2FaApGaQDPJQBK0LkNz2SrSYFLFAiUqjjE4TDbD8ABbm78vXsmST8cgF6OuOfxYYLOJdbIj5MC8ynguMc3lUoBFEgxZFDeSTvGu6R6XZF%2B0DSpYLiyBvagVK88IuTvSYFHokAnAfNQD0cBE7Lt4F3YdlwDcIvTgd3HzL8aoA9c9wAf80rilHQGqJmvJgVuTYFOoB5ABK7rriQhbEFflFLej4y52X3wKmxBVwzP1B0kLkhbB%2FBJ0ImsSL6TFLgTBQwpJwQ4NERRDTAUY1NrJbBZDcVN6gH4XFW9kMH%2BZy5xJejciZmym6SARwGjKNcQ4DDgQQlSBPhBvYKadTAq8%2FEoEhZyuVC8HYXe4YqPFnzXpgmp510CngQdjxPy96TAnSjQpA2Z7d01CFtDG1WzOmrderVwA0SAz9ki7RvwJOjciaGym6SARwGjSPqnpZQPvW%2B134Xk1L2%2FqlP6dFcjudl%2Bztp9viylvJugc2Y185ukwI0oYORZfVRKQSb58MMilbverI6bfpV0ZMcNpJCZPmLzQS3mNxJ0hpcxP0gK3JYChpoF2wyMwq4LXAEIKkdq2nc6KRdwf6v3adVagR8Anqi3C6Dzu2HQaciJFHh6IH49v%2B0yjLfedFoQ45vRiMnx3q5%2F0cbbu3%2FobCeo5h9ym57tIL%2BbT4GOGgMDL%2Bw8YfARpTFUN3oHdDy1DBnu%2Fw1SYBx0OgN75lnHg4O6%2FFobI8AG6Iys23DZxsudX2ggmNx3pofp9xadGUR%2Bc44CHfAZUrma%2BgSJB3vi8G2H%2F0yXe5N0%2FrksCyKbI8%2B3pZRfD0k6nbKGpyzskVGOvqMUmU7QmXxZ2uia5PvXKWCAD6QdAIgZ%2Fct7Fh6qHfCMChRMMh%2BJYl5xYhR0rPtxVGPTdVKPt5Cgc6BZSjrjbPSwX3TAB4crinB1H2Ev2oDH8F6pVwqfNCKvUg4GFwadwG2CochHjyhXf%2F%2Bpgs7VeeP7xpDIfaFiTvjvh5FCZ8wx2%2Fg%2FBQzwCdl7BPBAWoKk9AclAHBnz2nSDeKIVMNyZ23OBQcqmxk5IDxK8SGY%2B%2BcKOkb9lYeRQBMsbkOBs%2BBjeMjkILdbIE5KN2hvBzhhSacxNKrN80fWZb1853EjIPz%2B%2BIO4AvyBiNcN4RZ6q7w47G42nTZ%2BADFJGuscImLvVZZUwHbYxdqMjaA9xo%2Fvp5apvDpH%2Bb2gN8YLWrulFbxxNH4HHehQPcWL1I%2FSHn5Cm6Dv5fEakg%2Fo8aIX3%2BMAySpEXJBuVMAZAR15RQUm81wJZBpWsdrEEVoNjxNXCzhvYGEQmXkwmLWNwkOzpZiIBDYUm6YHILaVXWzGcd4v%2BtlAro0PY1vBpAijbFsUhIeTt0zjaaq4NuTq9DYHY2r0j5IG%2FAmtBZsfaKjRfzVWtmpxKvi3zc89GBuNWegC2peADBsEXLghQyjbXNw7KclEtV2Gad1oAfWhZxzFmMH%2F7pgbXcAXPd7GeLF2qMYXdoNbvKFIPq6xmZW2ANASWL1s92xh7a192WNRHP5Qzw48E7LpWOCieLNWMBrYLJ8M6oeH0ztwZ48czm6MSlbvKlJapwC%2F17kBHmJrRqIyzcWI0k1IdrxwE%2F3kqroNDBDYFc2lAe3f105mxd5HhxI2byRqNWqLALiObIKQW7ltVIxzxBPTlSRPbFi0h0A8eXicYQvN5uOCDzvEqLTpCD3oc2hE%2F%2BjNwwUdxZW2eUMa4%2FIq9GaZREU01gCHJAK8DnTFySg39C7r9hag006mrcYsHzuBTucuIpyEdGJZc5hiazHG4LbdGTskShL3QXeN6T6Qp7wGOq08wkiwYzcbutYKUJDxICTVYIlIHZKnchd4nHWEhEwnNQJiJUCrGeDGDQ54F7xB7Vn07QbjjSKQAqhYX%2FRx8HRdVKUwtEMZC228EdCRNhIpKVCINbXv2lAUoMBC4LtDtfn2LgCKM9PGoC1JjqrgE%2FNxoFptE2zyEOeRsr8%2BiqSD6F1zszDQkeEDWExIAgcR2YhvOmzeEwxF5Qvo05AdR5mzyoiGkfKQw6OADhhaU6XwrQXEmIOa3KjUC8Y8VRexYSBVaW0ATq9t8BVozh0oO3oY8S7gN4DfTtVo74K3OZiFD%2B4RflEk9510eUIy49270s3u4PYGbqkfbNNKe0%2FkpJVA1d2AwhWMDYIiQzvbCxvPkCFZmR9tDDRJfeFvMlSuoCJKPHZP6fa%2BvKRejYHw1oPNE7YHKY25dhzlFMbc8J1prFc28m6NO%2BEUaBMb7rBWHSPmbg7KAeUCq3GoHQqVnzG%2BN2kA%2FEvAA4CF5LBKiI1X%2Bc0LrslBMV%2B46nGUTxQNA%2FuVboVY16apwGdUqbB0EwYdJdX%2BsFEUFQvtd9Miaq3IwaAn5PVqY3E9QaMu80492pCYSx4U704gg06nLqY3MoJdRjVO4dAYaq2I%2F%2BEn%2FAYOZ4tPGZLGLsFQWZ%2BQhKjwgXYti7wVM0oLbFD8UQ8%2BdjBAgsGe6RqIlX3mHtxnQYeNDWsJp0vPAdLrBgcKaDpsg%2BqqV8rCWWKqlC68SvTDoBMl8iTQCQFOdExsoaWE914pBVJb%2BDlrx2mnMBgM4jw97inMxm5%2Ba4BOiIaK6gkvzqpuKO2Go6u9bxU%2BuflGtxZZCUkJHcRhphEvtkMLNrKz1QAh3UG9PeVtM0Fn5FTUdHqtBgdjYOiA3EYT8jJEiDwBdG7GfKNj0%2BariOKuusHoLqWVMOgp%2FLBtDG%2BD99ZNaXeTpsWtlWjGLLNg0Era3Xiwm%2FwtJEFFePDMO0L6X7iX9Ex7HYAb9QDypkzb68gYe6AjbTXbCWQssASSXnaqPPHR5FqT9Wqw1OjGPiu%2BjxCZbfohe5Psw%2FCKuHacJjUA5GWA51B1gFqrXGMeXoA1pafLK8q8uOTLvaOST0JzZfSWhna6ghcnPACYPyHV6sy6R76RfDgbdE6GBfChq8bwyNzkOz3QGToJRk4lJ4%2BLLm9fXc%2BjIDQBdNZ7oM8QU9lMFN1Lf8u7hVxPH9tAUDmkV82147Dv5UbDqTVaZ0fG3KySkhWnE6WhOOU56EiQQwzYiEgvA%2F1WSUkzNJdSnkXHe%2FW9pk7hECC%2BwL93HtqZoHMhhQFTXb15o5kBPRqpoKMYKle3oENsCgSj17p6aTD3gyYNEAhFrk4AnaHTn0kRFHH7dlMdIwGDIdC5YsdhoIP14dLI1b2D70lykG2HbUWNfpakw%2F9%2FxngpaHGqJ7E3sLaXwBMAfYo7i0T4TpG8mit82Njb5gTpBtI5ABFrHAri9BbKAh2pBnjtWL93xeFg2DlvO5JPMqTCXBFrT4xf0ikKOlLqDNtxGOhIdfnsmvLvKD9nOugYNsWrYybQkTwy3Y7XVGHQPHL4aPO6DDqGOh6h4S5uqxn7YQuiuQC0cYf5iNS59WuBjlU3JzJg%2Fk7oxGsMBvedzM%2Bx%2BjM33VVJJyrWBi64XxP6lmX5qmXaft9OCx7I6ILOFTsOJ57ilsXY3PwhZ8GxWV%2FdQr0ykoxPFSdnc0BNF%2BQU3Qx0OhHO8vDExgZPUBS4TKe5BDoXAEdV2c%2FkdFm8cwCdE2kFPb48FV3ZRFKKI9BSIUjtOlwidg%2FQ6QDOmsBoJe8pKqVXf1aTTsJ2HAE6UhoJu5%2B9k%2BYWoKOoXdM8Oso6TKFFB3CwDwDw4A8A9SEQ0wvC9dZArLUWOOo1AfDDIehdWwye5PanQ%2BkKryMNdKTHAHrdiGFV3gYYitdw9GIeRclfPbR9a9CxKqxZ%2BSyCGaQtwQQQEYVNzZxWA3o5dB6TeL%2FfEHRMl7c3pgA%2FwShOz5S4GIX30H7I6zMLdE5KOKOhCFCzgBNcdfyklPK3yLrsQGckNsdq3AuZjwxKe8c4RQ6u2TuAjpbv5F7b2k7uUBClUZBr2I4j6ai4vIeN5sbaTLfpNHpJWofjihzQ0VzmQ%2B54gw7S8B0yL7S5quEII%2FvFuKyv14SZZxbpV9lrIeCRoCOjTodPVkMXn8Xcbp7XHUBHnr5hdUc5zSz9WcvAn7EphpNzg8x3K9CR%2FDh0IjvAIzd5eB2DwIvXQuEXRlrLkE3HOKh6JNgSlJkLH141cuXjW5Jkftka4i5%2Bepf38UMp5Q2PZyToDMXmdKQdydyXFpT6iUQ%2B3wF05GnmGoPbSaa5rA90MVycs%2Bh3%2BVAJbrjwCd9oY7nMZa2gUzZCY8xwI3Oj%2FqW2DbU7BByGWhb6lu2NUe8k2ZUi7nsPR%2Bj3z0spf%2FRe3kBHIdppPVfJpzlITCwbt0aqsDXmdE%2B%2BO4COBGZ3g3VOoUgS4rC02TkMwGC8%2FhFeRTmOQ0kRRTWjUhWH8rG3sum0NZcHWOhub0rEtQJMDVPCSNuwCUHyWmlnSCuudNq5zncUdLQof2%2F%2Fz%2Fw9VEsHHXLQ6dbNGRmdoWKtC9D0TizYUO6VYdM5LIwCOp6HaAcinstcibwGaUxbQxu3rMFC5JSgczkex1sn5UBQC1HxdhTayxoyN1GvOhKit6bS0InxIrdql1xrrKVX9At8ixQKUj22ioqKzcyrLogQEbkXiPQh1YxJOlJd9Fhh1u%2FwyIGP3etvqMMVdHogcXZkSmLipo8bl8QD9MAUO5diOwm0FHxVvzdqpCCMG8wC3RS4skVojgYHdoLWaPy8MhzFHhEZsTC8bskmJd0oGI76lTVqtFPxEPDVqf8swfJmoNP4U3r98N9qdKwR8m%2Fd3wSe4LVx%2BDrtNlKjBeYJe5ssErc6Ejp3kIOvSZokPgTgEC%2BAZ2Bj4bzhSkniYLgn6ICPEX%2B2xmmNYgSBjtQHL8ctKJZ0npVsLXZ0%2FIiGVK8y7dxCSm13ayR7ko6h5kXGjcA2bBRew4WXcdBqHUfajbwjQadHf6q0yI2GvI8D2N9SvWInuQY8%2BJk2LM9l4uPtFilzJFG0w0vPSvvHQZIxDtTeGq2SZivFOhQ4KkBH2qgifBF9B2MEaAJokI5kFnyLNEigc4jNQWJcpAHrHaNolWR%2BMBKSIKOh4m7hoIAV%2FzLoNOCxYockSTa3pCJR8uTGu4FOYCNry2rS%2Fh6gM0hzGn8oRqYjTfW2gNm2obZpbW11aZTDcshTF4yEjm5pSrrG35BmTqU7WJ0Vdicxf%2Bd0gR6BvgAVJLvRs6tP3BabClRDFeF3DdE3VHw7jLIsZBvqFNe90RakC34FDewt2wnWqwMkiciM4dsVNe0dGvOurzbfXX%2FNkAvRHOPkAWtRBom8t5XTNOZgpaCQFAF6QbpUT7imAvPiYId17g2ySQfbens3irBSsbwOM76n1BOznK0zDuJFuZ6cF1dVyVMr2nri4Ab%2Fk9TIU2N2bbA8PurrK9w7FVlcdoigH%2FRJe8n7HHwq0zFwEF6SZLxO3cLsXgP5%2B%2BtFARazAXX4psw3g3JsvDDWTT2RedvtIr%2BHpwcDIEofouqARBtSn59sff8H57piU0311KcAAAAASUVORK5CYII%3D%22%2F%3E%0A%3C%2Fdefs%3E%0A%3C%2Fsvg%3E%0A)
A Study of MEDI9253 in combination with durvalumab in select solid tumors
Study identifier:D7880C00001
ClinicalTrials.gov identifier:NCT04613492
EudraCT identifier:2020-002294-96
CTIS identifier:N/A
Study Complete
Official Title
An Open-label, Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MEDI9253, a Recombinant Newcastle Disease Virus Encoding Interleukin-12, in Combination with Durvalumab in Participants with Select Advanced/Metastatic Solid Tumors
Medical condition
Solid Tumors
Phase
Phase 1
Healthy volunteers
No
Study drug
-
Sex
All
Actual Enrollment
40
Study type
Interventional
Age
18 Years - 101 Years
Date
Study Start Date: 02 Dec 2020
Primary Completion Date: 31 May 2024
Study Completion Date: 31 May 2024
Study design
Allocation: Non-randomized
Endpoint Classification: -
Intervention Model: Parallel Assignment
Masking: -
Primary Purpose: Treatment
Verification:
Verified 01 Jun 2024 by AstraZeneca
Sponsors
AstraZeneca
Collaborators
-
Inclusion and exclusion criteria
Location
Research Site
Saint Louis, MO, United States, 63110
Location
Research Site
New York, NY, United States, 10032
Location
Research Site
Pittsburgh, PA, United States, 15232
Location
Research Site
New York, NY, United States, 10065
Location
Research Site
Buffalo, NY, United States, 14263
Location
Research Site
Bordeaux, France, 33076
Location
Research Site
Villejuif, France, 94800
Location
Research Site
Toulouse, France, 31100
| Arms | Assigned Interventions |
|---|---|
| Experimental: Single dose MEDI9253, sequential Durvalumab Various dose level cohorts for single dose MEDI9253 with sequential Durvalumab dosing | Biological/Vaccine: MEDI9253 Participants will receive either Single dose MEDI9253 or Multiple Dose MEDI9253; sequentially or concurrent with Durvalumab Biological/Vaccine: Durvalumab Durvalumab treatment will be started sequentially or concurrently with MEDI9253 |
| Experimental: Multiple dose MEDI9253, sequential Durvalumab Various dose level cohorts for multiple dose MEDI9253 with sequential Durvalumab dosing; | Biological/Vaccine: MEDI9253 Participants will receive either Single dose MEDI9253 or Multiple Dose MEDI9253; sequentially or concurrent with Durvalumab Biological/Vaccine: Durvalumab Durvalumab treatment will be started sequentially or concurrently with MEDI9253 |
| Experimental: Multiple dose MEDI9253, concurrent Durvalumab Various dose level cohorts for multiple dose MEDI9253 with concurrent Durvalumab dosing. | Biological/Vaccine: MEDI9253 Participants will receive either Single dose MEDI9253 or Multiple Dose MEDI9253; sequentially or concurrent with Durvalumab Biological/Vaccine: Durvalumab Durvalumab treatment will be started sequentially or concurrently with MEDI9253 |
"There is no result for the study"
Contacts
Contact
AstraZeneca Clinical Study Information Center
%22%2F%3E%0A%3Cdefs%3E%0A%3Cpattern%20id%3D%22pattern0%22%20patternContentUnits%3D%22objectBoundingBox%22%20width%3D%221%22%20height%3D%221%22%3E%0A%3Cuse%20xlink%3Ahref%3D%22%23image0_8556_33445%22%20transform%3D%22translate(0%200.0591543)%20scale(0.00350877%200.0125956)%22%2F%3E%0A%3C%2Fpattern%3E%0A%3Cimage%20id%3D%22image0_8556_33445%22%20width%3D%22285%22%20height%3D%2270%22%20xlink%3Ahref%3D%22data%3Aimage%2Fpng%3Bbase64%2CiVBORw0KGgoAAAANSUhEUgAAAR0AAABGCAYAAADxVED7AAAAAXNSR0IArs4c6QAAE2xJREFUeF7tXY3xJUUR38nAIwHFBBQTQEhAMAE5E1BMQDABIAG9iwCMgCMCIQGBCCCDsX7r9FZvb%2Fd0z%2B68938cvVVXd3Vvdz56en7T31OWfJICSYGfNQVqrb8FAUopX9%2BDEOUenWQfSYGkwGNRoNb6i2VZ%2FrIsy1%2BXZcG%2F8fy4LMunpZSPbznaBJ1bUjfbTgo8IAVqrQCbjxjYyFG%2BKKU8v9XQE3RuRdlsNynwYBRo0s0ny7J8EBjaB6WUl4H3hl9J0BkmWX6QFPjpUaDW%2BqtlWb5clgV%2FR56vSylvRV4cfSdBZ5Ri%2BX5S4CdGgROAQzN8p5TyavZ0E3RmUzTbSwo8EAUuAA5m8VkpBYbmqU%2BCzlRyZmNJgcehwEXAwURelVLemT2jBJ3ZFM32kgIPQIEJgINZ%2FFhKeTZ7Ogk6syma7SUFnpgCkwCHZvFmKeW7mVNK0JlJzWwrKfDEFJgMOJjN81LKi5nTStCZSc1sKynwhBRocTj%2FGXCLR0b7YSnl08iL0XcSdKKUyveSAg9OgVorAGfNowo8ny3LAgnmcwekpkcnJ%2BgEVidfSQo8OgVqrYg0jrq3N%2Bml1opv8K31%2FLuU8t7M%2BSfozKRmtpUUeAIK1Fr%2F3nKpvN6R0AnA2Ww0tVYACqQd65kemZyg4y1T%2Fp4UeGAKtOTNqM3lLVm%2Bohmev%2B1M8btSypszSZCgM5Oa2VZS4I4UqLX%2BvuVTRXo1vVC11tppYHqsToJOZLnynaTAg1Fg0DXedXvXWiHpmImgpZSpODG1sQdblxxOUuC1pMBMwAGBaq3IPofUpD4JOq8lG%2BWkkgJxCgy4xkOBfbVWGJb%2F1BnB1KjklHTia51vJgWenAIDnqoQ4DRJB1UE4QGzngSdJ1%2F5HEBS4Ako4HiqIK1slf5G6uAEYnUSdJ5gvbPLpMCTUqDd2ICIY%2B1BIfUflLrHuN0BsTnfLMuCb7%2FXwKjWivKl%2F%2BpM8OBqv0KMVK%2BuUC%2B%2FTQrcgQIBwzHKilqApI0QYPQV6uUsy0LABBXrN4ZBeWoFwQSdOzBNdpEUuEIBz7u0LAuC93oBfl73KF0BAMIfSEVwnyNS%2Be327wQdj4L5e1LgdaFA0HCMQlsAHbq%2FCvlU%2BBMtwi7JRZLQF%2B0HRCVPq6mTks7rwp05j9eOAoEUBcx59VLVWpEKgfus8Kw2mBaxDHtNzx3u0Y2kICR%2BEgh533R%2FT9C5RL78OClwGwoEa%2BNsbnGREvFxKQU2mvVp4IXgP7jFz0o%2FaApGaQDPJQBK0LkNz2SrSYFLFAiUqjjE4TDbD8ABbm78vXsmST8cgF6OuOfxYYLOJdbIj5MC8ynguMc3lUoBFEgxZFDeSTvGu6R6XZF%2B0DSpYLiyBvagVK88IuTvSYFHokAnAfNQD0cBE7Lt4F3YdlwDcIvTgd3HzL8aoA9c9wAf80rilHQGqJmvJgVuTYFOoB5ABK7rriQhbEFflFLej4y52X3wKmxBVwzP1B0kLkhbB%2FBJ0ImsSL6TFLgTBQwpJwQ4NERRDTAUY1NrJbBZDcVN6gH4XFW9kMH%2BZy5xJejciZmym6SARwGjKNcQ4DDgQQlSBPhBvYKadTAq8%2FEoEhZyuVC8HYXe4YqPFnzXpgmp510CngQdjxPy96TAnSjQpA2Z7d01CFtDG1WzOmrderVwA0SAz9ki7RvwJOjciaGym6SARwGjSPqnpZQPvW%2B134Xk1L2%2FqlP6dFcjudl%2Bztp9viylvJugc2Y185ukwI0oYORZfVRKQSb58MMilbverI6bfpV0ZMcNpJCZPmLzQS3mNxJ0hpcxP0gK3JYChpoF2wyMwq4LXAEIKkdq2nc6KRdwf6v3adVagR8Anqi3C6Dzu2HQaciJFHh6IH49v%2B0yjLfedFoQ45vRiMnx3q5%2F0cbbu3%2FobCeo5h9ym57tIL%2BbT4GOGgMDL%2Bw8YfARpTFUN3oHdDy1DBnu%2Fw1SYBx0OgN75lnHg4O6%2FFobI8AG6Iys23DZxsudX2ggmNx3pofp9xadGUR%2Bc44CHfAZUrma%2BgSJB3vi8G2H%2F0yXe5N0%2FrksCyKbI8%2B3pZRfD0k6nbKGpyzskVGOvqMUmU7QmXxZ2uia5PvXKWCAD6QdAIgZ%2Fct7Fh6qHfCMChRMMh%2BJYl5xYhR0rPtxVGPTdVKPt5Cgc6BZSjrjbPSwX3TAB4crinB1H2Ev2oDH8F6pVwqfNCKvUg4GFwadwG2CochHjyhXf%2F%2Bpgs7VeeP7xpDIfaFiTvjvh5FCZ8wx2%2Fg%2FBQzwCdl7BPBAWoKk9AclAHBnz2nSDeKIVMNyZ23OBQcqmxk5IDxK8SGY%2B%2BcKOkb9lYeRQBMsbkOBs%2BBjeMjkILdbIE5KN2hvBzhhSacxNKrN80fWZb1853EjIPz%2B%2BIO4AvyBiNcN4RZ6q7w47G42nTZ%2BADFJGuscImLvVZZUwHbYxdqMjaA9xo%2Fvp5apvDpH%2Bb2gN8YLWrulFbxxNH4HHehQPcWL1I%2FSHn5Cm6Dv5fEakg%2Fo8aIX3%2BMAySpEXJBuVMAZAR15RQUm81wJZBpWsdrEEVoNjxNXCzhvYGEQmXkwmLWNwkOzpZiIBDYUm6YHILaVXWzGcd4v%2BtlAro0PY1vBpAijbFsUhIeTt0zjaaq4NuTq9DYHY2r0j5IG%2FAmtBZsfaKjRfzVWtmpxKvi3zc89GBuNWegC2peADBsEXLghQyjbXNw7KclEtV2Gad1oAfWhZxzFmMH%2F7pgbXcAXPd7GeLF2qMYXdoNbvKFIPq6xmZW2ANASWL1s92xh7a192WNRHP5Qzw48E7LpWOCieLNWMBrYLJ8M6oeH0ztwZ48czm6MSlbvKlJapwC%2F17kBHmJrRqIyzcWI0k1IdrxwE%2F3kqroNDBDYFc2lAe3f105mxd5HhxI2byRqNWqLALiObIKQW7ltVIxzxBPTlSRPbFi0h0A8eXicYQvN5uOCDzvEqLTpCD3oc2hE%2F%2BjNwwUdxZW2eUMa4%2FIq9GaZREU01gCHJAK8DnTFySg39C7r9hag006mrcYsHzuBTucuIpyEdGJZc5hiazHG4LbdGTskShL3QXeN6T6Qp7wGOq08wkiwYzcbutYKUJDxICTVYIlIHZKnchd4nHWEhEwnNQJiJUCrGeDGDQ54F7xB7Vn07QbjjSKQAqhYX%2FRx8HRdVKUwtEMZC228EdCRNhIpKVCINbXv2lAUoMBC4LtDtfn2LgCKM9PGoC1JjqrgE%2FNxoFptE2zyEOeRsr8%2BiqSD6F1zszDQkeEDWExIAgcR2YhvOmzeEwxF5Qvo05AdR5mzyoiGkfKQw6OADhhaU6XwrQXEmIOa3KjUC8Y8VRexYSBVaW0ATq9t8BVozh0oO3oY8S7gN4DfTtVo74K3OZiFD%2B4RflEk9510eUIy49270s3u4PYGbqkfbNNKe0%2FkpJVA1d2AwhWMDYIiQzvbCxvPkCFZmR9tDDRJfeFvMlSuoCJKPHZP6fa%2BvKRejYHw1oPNE7YHKY25dhzlFMbc8J1prFc28m6NO%2BEUaBMb7rBWHSPmbg7KAeUCq3GoHQqVnzG%2BN2kA%2FEvAA4CF5LBKiI1X%2Bc0LrslBMV%2B46nGUTxQNA%2FuVboVY16apwGdUqbB0EwYdJdX%2BsFEUFQvtd9Miaq3IwaAn5PVqY3E9QaMu80492pCYSx4U704gg06nLqY3MoJdRjVO4dAYaq2I%2F%2BEn%2FAYOZ4tPGZLGLsFQWZ%2BQhKjwgXYti7wVM0oLbFD8UQ8%2BdjBAgsGe6RqIlX3mHtxnQYeNDWsJp0vPAdLrBgcKaDpsg%2BqqV8rCWWKqlC68SvTDoBMl8iTQCQFOdExsoaWE914pBVJb%2BDlrx2mnMBgM4jw97inMxm5%2Ba4BOiIaK6gkvzqpuKO2Go6u9bxU%2BuflGtxZZCUkJHcRhphEvtkMLNrKz1QAh3UG9PeVtM0Fn5FTUdHqtBgdjYOiA3EYT8jJEiDwBdG7GfKNj0%2BariOKuusHoLqWVMOgp%2FLBtDG%2BD99ZNaXeTpsWtlWjGLLNg0Era3Xiwm%2FwtJEFFePDMO0L6X7iX9Ex7HYAb9QDypkzb68gYe6AjbTXbCWQssASSXnaqPPHR5FqT9Wqw1OjGPiu%2BjxCZbfohe5Psw%2FCKuHacJjUA5GWA51B1gFqrXGMeXoA1pafLK8q8uOTLvaOST0JzZfSWhna6ghcnPACYPyHV6sy6R76RfDgbdE6GBfChq8bwyNzkOz3QGToJRk4lJ4%2BLLm9fXc%2BjIDQBdNZ7oM8QU9lMFN1Lf8u7hVxPH9tAUDmkV82147Dv5UbDqTVaZ0fG3KySkhWnE6WhOOU56EiQQwzYiEgvA%2F1WSUkzNJdSnkXHe%2FW9pk7hECC%2BwL93HtqZoHMhhQFTXb15o5kBPRqpoKMYKle3oENsCgSj17p6aTD3gyYNEAhFrk4AnaHTn0kRFHH7dlMdIwGDIdC5YsdhoIP14dLI1b2D70lykG2HbUWNfpakw%2F9%2FxngpaHGqJ7E3sLaXwBMAfYo7i0T4TpG8mit82Njb5gTpBtI5ABFrHAri9BbKAh2pBnjtWL93xeFg2DlvO5JPMqTCXBFrT4xf0ikKOlLqDNtxGOhIdfnsmvLvKD9nOugYNsWrYybQkTwy3Y7XVGHQPHL4aPO6DDqGOh6h4S5uqxn7YQuiuQC0cYf5iNS59WuBjlU3JzJg%2Fk7oxGsMBvedzM%2Bx%2BjM33VVJJyrWBi64XxP6lmX5qmXaft9OCx7I6ILOFTsOJ57ilsXY3PwhZ8GxWV%2FdQr0ykoxPFSdnc0BNF%2BQU3Qx0OhHO8vDExgZPUBS4TKe5BDoXAEdV2c%2FkdFm8cwCdE2kFPb48FV3ZRFKKI9BSIUjtOlwidg%2FQ6QDOmsBoJe8pKqVXf1aTTsJ2HAE6UhoJu5%2B9k%2BYWoKOoXdM8Oso6TKFFB3CwDwDw4A8A9SEQ0wvC9dZArLUWOOo1AfDDIehdWwye5PanQ%2BkKryMNdKTHAHrdiGFV3gYYitdw9GIeRclfPbR9a9CxKqxZ%2BSyCGaQtwQQQEYVNzZxWA3o5dB6TeL%2FfEHRMl7c3pgA%2FwShOz5S4GIX30H7I6zMLdE5KOKOhCFCzgBNcdfyklPK3yLrsQGckNsdq3AuZjwxKe8c4RQ6u2TuAjpbv5F7b2k7uUBClUZBr2I4j6ai4vIeN5sbaTLfpNHpJWofjihzQ0VzmQ%2B54gw7S8B0yL7S5quEII%2FvFuKyv14SZZxbpV9lrIeCRoCOjTodPVkMXn8Xcbp7XHUBHnr5hdUc5zSz9WcvAn7EphpNzg8x3K9CR%2FDh0IjvAIzd5eB2DwIvXQuEXRlrLkE3HOKh6JNgSlJkLH141cuXjW5Jkftka4i5%2Bepf38UMp5Q2PZyToDMXmdKQdydyXFpT6iUQ%2B3wF05GnmGoPbSaa5rA90MVycs%2Bh3%2BVAJbrjwCd9oY7nMZa2gUzZCY8xwI3Oj%2FqW2DbU7BByGWhb6lu2NUe8k2ZUi7nsPR%2Bj3z0spf%2FRe3kBHIdppPVfJpzlITCwbt0aqsDXmdE%2B%2BO4COBGZ3g3VOoUgS4rC02TkMwGC8%2FhFeRTmOQ0kRRTWjUhWH8rG3sum0NZcHWOhub0rEtQJMDVPCSNuwCUHyWmlnSCuudNq5zncUdLQof2%2F%2Fz%2Fw9VEsHHXLQ6dbNGRmdoWKtC9D0TizYUO6VYdM5LIwCOp6HaAcinstcibwGaUxbQxu3rMFC5JSgczkex1sn5UBQC1HxdhTayxoyN1GvOhKit6bS0InxIrdql1xrrKVX9At8ixQKUj22ioqKzcyrLogQEbkXiPQh1YxJOlJd9Fhh1u%2FwyIGP3etvqMMVdHogcXZkSmLipo8bl8QD9MAUO5diOwm0FHxVvzdqpCCMG8wC3RS4skVojgYHdoLWaPy8MhzFHhEZsTC8bskmJd0oGI76lTVqtFPxEPDVqf8swfJmoNP4U3r98N9qdKwR8m%2Fd3wSe4LVx%2BDrtNlKjBeYJe5ssErc6Ejp3kIOvSZokPgTgEC%2BAZ2Bj4bzhSkniYLgn6ICPEX%2B2xmmNYgSBjtQHL8ctKJZ0npVsLXZ0%2FIiGVK8y7dxCSm13ayR7ko6h5kXGjcA2bBRew4WXcdBqHUfajbwjQadHf6q0yI2GvI8D2N9SvWInuQY8%2BJk2LM9l4uPtFilzJFG0w0vPSvvHQZIxDtTeGq2SZivFOhQ4KkBH2qgifBF9B2MEaAJokI5kFnyLNEigc4jNQWJcpAHrHaNolWR%2BMBKSIKOh4m7hoIAV%2FzLoNOCxYockSTa3pCJR8uTGu4FOYCNry2rS%2Fh6gM0hzGn8oRqYjTfW2gNm2obZpbW11aZTDcshTF4yEjm5pSrrG35BmTqU7WJ0Vdicxf%2Bd0gR6BvgAVJLvRs6tP3BabClRDFeF3DdE3VHw7jLIsZBvqFNe90RakC34FDewt2wnWqwMkiciM4dsVNe0dGvOurzbfXX%2FNkAvRHOPkAWtRBom8t5XTNOZgpaCQFAF6QbpUT7imAvPiYId17g2ySQfbens3irBSsbwOM76n1BOznK0zDuJFuZ6cF1dVyVMr2nri4Ab%2Fk9TIU2N2bbA8PurrK9w7FVlcdoigH%2FRJe8n7HHwq0zFwEF6SZLxO3cLsXgP5%2B%2BtFARazAXX4psw3g3JsvDDWTT2RedvtIr%2BHpwcDIEofouqARBtSn59sff8H57piU0311KcAAAAASUVORK5CYII%3D%22%2F%3E%0A%3C%2Fdefs%3E%0A%3C%2Fsvg%3E%0A)
