A Study of Absorption, Distribution, Metabolism and Excretion (ADME) of [14C]AZD4144

Inclusion Criteria

• Inclusion Criteria:
• - Healthy males aged 30 to 65 years inclusive
• - BMI of 18.0 to 32.0 kg/m2 inclusive
• - Regular bowel movements (i.e. average stool production of ≥1 and ≤3 stools per day)
• Exclusion Criteria:
• - History of any clinically important disease or disorder
• - History or presence of clinically significant cardiovascular, renal, respiratory, gastrointestinal disease, or neurological or psychiatric disorder
• - Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of the first dosing day
• - Acute diarrhoea or constipation within 7 days of the first dosing day
• - Participants who do not have suitable veins for multiple venepunctures/cannulation
• - Clinically significant abnormal clinical chemistry, haematology, coagulation or urinalysis
• - Any clinically significant abnormal findings in vital signs
• - Any clinically significant abnormalities on 12-lead ECG
• - Evidence of renal impairment
• - Participants who have received any IMP in the last 90 days prior to the first dosing day
• - Participants who have previously received AZD4144
• - Radiation exposure exceeding 5 mSv in the last 12 months or 10 mSv in the last 5 years, occupationally exposed worker, or have been administered IMP in a radiolabelled ADME study in the last 12 months.
• - Blood or plasma donation, or loss of more than 400 mL blood during the 3 months prior to the study.
• - Use of any prescribed or non-prescribed medication including antacids, gastric pH modifying agents, analgesics, herbal remedies, vitamins and minerals within 2 weeks of the first dosing day
• - Use of drugs or herbal medications with CYP3A4 enzyme-inducing properties such as St John’s Wort or CYP3A4 inhibiting properties within 3 weeks of the first dosing day
• - Current smokers or known or suspected history of alcohol or drug abuse
• - Excessive intake of caffeine-containing drinks or food