Esomeprazole in PPI Failures - IMPROVE

Exclusion Criteria

• - Any treatment with esomeprazole during 30 days prior to enrolment
• History of esophageal, gastric or duodenal surgery, except for simple closure of an ulcer
• - Current or historical evidence of the following diseases/conditions, as judged by the investigator:Zollinger-Ellison syndrome,Primary esophageal motility disorder, i.e. achalasia, scleroderma, primary esophageal spasm,
• - Gastric or duodenal ulcers within the last three months, Malabsorbtion
• - Malignancy or other concomitant disease with poor prognosis or which may interfere with the assessments in the study
• - Unstable diabetes mellitus. Stable diabetes controlled by diet, oral agents or insulin is acceptable
• - Patients with severe diseases or disorders which may interfere with the conduct of the study